Desolate can be defined as “a place deserted of people and in a state of bleak and dismal emptiness”.
The prophet Jeremiah speaks of people that choose not to build with a corner stone will be desolate forever. 
What do I get from that?: People who haven’t built their life founded upon Jesus will be left wanting. 
Know what/who you are building your life upon. Make sure that Jesus is at the base of everything you do. Only this foundation will lead to a prosperous life filled with abundance.